Main description:

The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.

Contents:

Foreword; Leonid Sazanov

Part I: Structure and mechanism of complex I
1. Structure of complex I; Rouslan Efremov and Leonid Sazanov
2. On the mechanism of the respiratory complex I; Thorsten Friedrich, Petra Hellwig, and Oliver Einsle
3. Iron-sulfur clusters in complex I; Eiko Nakamaru-Ogiso
4. Current Topics of the Inhibitors of Mitochondrial Complex I; Hideto Miyoshi
5. My Fifty Years Association with Complex I Study; Tomoko Ohnishi

Part II: Evolution of complex I
6. The Evolutionary Relationship between Complex I and [NiFe]-hydrogenase; Anne Volbeda and Juan C. Fontecilla-Camps
7. Recruitment of the antiporter module - a key event in complex I evolution; Vamsi Krishna Moparthi and Cecilia Hagerhall

Part III: Mutations in complex I subunits and medical implications
8. Characterization of Bacterial Complex I (NDH-1) by a Genetic Engineering Approach; Takao Yagi, Jesus Torres-Bacete, Prem Kumar Sinha, Norma Castro-Guerrero, and Akemi Matsuno-Yagi
9. Cellular consequences of mtDNA-encoded mutations in NADH:ubiquinone oxidoreductase; Mina Pellegrini, Jan A.M. Smeitink, Peter H.G.M. Willems and Werner J.H. Koopman

Part IV: Subunit composition and assembly of mitochondrial complex I
10. The assembly of human complex I; Jessica Nouws, Maria Antonietta Calvaruso, Leo Nijtmans
11. Complexes I in the green lineage; Claire Remacle, Patrice Hamel, Veronique Larosa, Nitya Subrahmanian, Pierre Cardol

Part V: Supercomplexes in mitochondria
12. Supramolecular organization of the respiratory chain; Janet Vonck

Index