Main description:

This book focuses on state-of-the-art microfluidic research in medical and biological applications. The top-level researchers in this research field explain carefully and clearly what can be done by using microfluidic devices. Beginners in the field -undergraduates, engineers, biologists, medical researchers-will easily learn to understand microfluidic-based medical and biological applications. Because a wide range of topics is summarized here, it also helps experts to learn more about fields outside their own specialties. The book covers many interesting subjects, including cell separation, protein crystallization, single-cell analysis, cell diagnosis, point-of-care testing, immunoassay, embyos/worms on a chip and organ-on-a-chip. Readers will be convinced that microfluidic devices have great potential for medical and biological applications.

Contents:

Chapter 1: Acoustofluidic blood component sample preparation and processing in medical applications

Maria Antfolk and Thomas Laurell

Chapter 2: Microfluidic technologies and platforms for protein crystallography
Masatoshi Maeki and Manabu Tokeshi

Chapter 3: Application of Sers-based Microfluidics for in Vitro Diagnostics
Jinhyeok Jeon, Namhyun Choi, Joung-Il Moon, Hao Chen and Jaebum Choo

Chapter 4: Miniaturized Electrochemical Sensors to Facilitate Liquid Biopsy for Detection of Circulating Tumor Markers
Yi-Ge Zhou, Leyla Kermanshah, Libing Zhang and Reza M. Mohamadi

Chapter 5: Spiral Inertial Microfluidics for Cell Separation and Biomedical Applications
Ning Liu, Chayakorn Petchakup, Hui Min Tay, King Ho Holden Li and Han Wei Hou

Chapter 6: Worms on a Chip
Han-Sheng Chuang, Wen-Hui Wang, Chang-Shi Chen

Chapter 7: Microfluidic devices for gamete processing and analysis, fertilization and embryo culture and characterization
Severine Le Gac, Verena Nordhoff, Bastien Venzac

Chapter 8: Microfluidic organs-on-chips to reconstitute cellular microenvironments

Yu-suke Torisawa

Chapter 9: In vitro tissue construction for organ-on-a-chip applications
Yuya Morimoto, Nobuhito Mori and Shoji Takeuchi

Chapter 10: Nanobiodevices for Cancer Diagnostics and Stem Cell Therapeutics

D. Onoshima, H. Yukawa and Y. Baba

Chapter 11: Nanopore Device for Single-Molecule Sensing Method and Its Application

Masateru Taniguchi and Takahito Ohshiro

Chapter 12: Paper Microfluidics for POC Testing in Low-resource Settings

Elain Fu

Chapter 13: Paper-Based Microfluidics for Point-of-Care Medical DiagnosticsKentaro Yamada and Daniel Citterio