Main description:

This is the first book to cover every angle in the clinical application of biologics. Readers will not only find that all of the biologics currently approved for clinical use are delineated in a standardized way, but also the "differential therapy" with biologics in fields including dermatology and neurology is described in detail and summarized in treatment algorithms. Shorter sections on biologic biotechnology as well as safety and regulatory issues complement the more clinically-oriented central chapters.

Contents:

Introduction: Definition and Classification of Biologics.- Introduction: Definition and Classification of Biologics.- Development and Pre-clinical Pharmacology of Biologics.- Infliximab: From the Idea to the Product.- Adalimumab.- Etanercept.- Efalizumab: Antibody Characteristics, Mode of Action and Preclinical Development.- Monoclonal Antibody Targeted Radiation Cancer Therapy.- The Production of Biopharmaceuticals.- Disease-Specific Applications and Clinical Trials.- Treating Autoimmune Bullous Skin Disorders with Biologics.- Biologics in Psoriasis.- Biologic Agents in Psoriatic Arthritis.- Biologic Therapies for Rheumatoid Arthritis Targeting TNF-? and IL-1.- Biologics in Crohn's Disease and Ulcerative Colitis: Focus on Tumor Necrosis Factor Antagonists.- Multiple Sclerosis: New Immunobiologics.- Biologics in Cutaneous Lymphoma.- Biologics in Targeted Cancer Therapy.- Safety and Perspectives.- Safety Aspects of Biologics: Lessons Learnt from Monoclonal Antibodies.- New Biological Therapeutics in the Genome Age.- Evidence Based Medicine's Perspective on Biologics.