Published November, 2010
By John Parkinson
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Over the past two decades, expressed sequence tags (ESTs - single pass reads from randomly selected cDNAs), have proven to be a remarkably cost-effective route for the purposes of gene discovery.

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Published November, 2010
By Alexander Serganov
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

The discovery of RNA interference and multiple bacterial regulatory RNAs caused a shift from the perception of proteins as the predominant regulators of gene expression to the acknowledgement of the importance of RNAs in many regulatory circuits.

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Published November, 2010
By Michael Zachariou
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Thirty-eight years after its introduction, affinity chromatography remains a key tool in the armory of separation techniques available to separation and interaction scientists.

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Published November, 2010
By Axel H. Schonthal and Axel H. Schoenthal
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired.

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Published November, 2010
By William J. Murphy
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

The past decade has seen the emergence of a new field of scientific inquiry at the intersection of phylogenetics and genomics: phylogenomics.

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Published November, 2010
By Gregg B. Fields
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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This book is dedicated to the characterization of peptides and their applications for the study of biochemical systems. Part II, Application, presents a variety of specific applications for synthetic peptides. This book is an indispensable aid in the pursuit of new directions in peptide research.

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Published November, 2010
By Inka Brockhausen
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Another challenge for future research is to understand the glycodynamics of a cell, that is, how the cell responds to stimuli leading to biological and pathological changes in terms of alterations in glycosylation, and how this affects the biology of the cell.

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Published November, 2010
By Laura E. Nagy
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Sections present clearly defined models of ethanol exposure, recent advances in the development of specific methodologies to mimic the impact of ethanol metabolism in cultured cells, and methodologies to investigate a variety of cells and tissues that are known to be disrupted by ethanol, amongst other topics.

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Published November, 2010
By Andreas Kukol
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Molecular modeling has undergone a remarkable transformation in the last 20 years. This book provides thorough introductions and a compilation of step-by-step methods applicable to problems faced by non-specialists - especially those new to the software packages used in molecular modeling.

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Published November, 2010
By Jang B. Rampal
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Coverage includes applications in DNA, peptide, antibody and carbohydrate microarraying, oligonucleotide microarrays generated from hydrolysis PCR probe sequences, microarray platforms in clinical practice, and screening of cDNA libraries on glass slide microarrays.

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