Published November, 2010
By Bryan John Smith
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Determination of the protein sequence is as important today as it was a half century ago, even though the techniques and purposes have changed over time. The first edition of Protein Sequencing Protocols was a "snapshot" of methods in use in protein biochemistry laboratories at the time, and this, the second edition, is likewise.

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Published November, 2010
By Janet J. Maguire and Anthony P. Davenport
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

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Published November, 2010
By Axel H. Schonthal and Axel H. Schoenthal
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired.

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Published November, 2010
By Eric Fung
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Protein Arrays: Methods and Protocols is an introduction to protein array technology and its application to the multiplexed detection of proteins. Although protein array technology has some roots in gene array technology, it can only be described as a distant relative.

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Published November, 2010
By Jurgen Bajorath
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Published November, 2010
By Tuan Vo-Dinh
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Among the highlights are techniques for the in vivo tracking of biochemical processes using fluorescent molecular probes and nanosensors, and the exploration of biochemical processes and submicroscopic structures of living cells at unprecedented resolutions using near-field optics.

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Published November, 2010
By Ed Manser and Thomas Leung
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. Some of the techniques grouped in the first section apply broadly to small GTPases, whereas others in Part II are more applicable within each GTPase subfamily.

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Published November, 2010
By Jonathan M. Gibbins and Martyn P. Mahaut-Smith
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles.

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Published November, 2010
By Daniele D'Ambrosio and Francesco Sinigaglia
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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The disparity between the large number of chemokines and that smaller number of receptors is balanced by the promiscuity in ligand-receptor interactions, with multiple chemokines binding to the same receptor and several chemokines binding to more than one receptor.

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Published November, 2010
By B. Paul Morgan
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

The complement system, first described more than a century ago, was for many years the ugly duckling of the immunology world, but no more.

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