Published December, 2020
By Vance Berger
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This book deals with randomization in clinical trials. Currently trials use permuted blocks randomization almost exclusively. Many researchers are aware of the drawbacks to this fatally flawed method, and while many are unaware of any better randomization methods, in fact several groups have proposed improvements, and also demonstrated the benef

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Published December, 2020
By Marc Buyse, Shigeyuki Matsui and Richard Simon
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This book offers statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics. The book explains how to identify molecular biomarkers using DNA microarrays, validate the developed biomarkers, and confirm

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Published December, 2020
By Sandeep M Menon, Kerry B. Barker, Siyan Xu, Ralph B. D'Agostino, Sr., Bo Jin, PhD, Sr. D'Agostino and PhD Jin
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

Biosimilars have the potential to change the way we think about, identify, and manage health problems. They are already impacting both clinical research and patient care, and this impact will only grow as our understanding and technologies improve. Written by a team of experienced specialists in clinical development, this book discusses various

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Published December, 2020
By Monika Maya Wahi, Peter Seebach and Monika Wahi
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This book discusses how to do routine health data analysis, typically done in SAS, in R. It assumes that the audience has some experience in this area. Many SAS users want to try R, but R developers have not focused on health data analysis cookbooks. This book will allow them to add R to their analytic skills toolbox.

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Published December, 2020
By Ronald B. Geskus
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This practical and thorough book explains when and how to use models and techniques for the analysis of competing risks and intermediate states. It covers the most recent insights on estimation techniques and discusses in detail how to interpret the obtained results. Each chapter includes standard exercises; a software section on SAS, Stata, and

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Published December, 2020
By Ross L. Prentice and Shanshan Zhao
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

Though much has been written on multivariate failure time data analysis methods, a unified approach to this topic has yet to be communicated. This book aims to fill that gap through a novel focus on marginal hazard rates and cross ratio modeling. Readers will find the content useful for instruction, for application in collaborative research and

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Published December, 2020
By Hui Quan and Joshua Chen
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This book presents a comprehensive overview on the current status of conducting MRCTs in clinical development. It first provides a high-level introduction to the context, motivation, opportunities, and challenges in simultaneous global clinical development using MRCTs. It then focuses on the design, monitoring, and analysis/interpretation of MRC

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Published December, 2020
By Ding-Geng (Din) Chen, Karl E. Peace and Pinggao Zhang
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This book will provide a thorough presentation of clinical trial methodology with detailed step-by-step illustrations on implementation in software R/SAS. The examples will be based on actual experience of the authors in many areas of clinical drug development. Actual examples of clinical trials will be presented and after understanding the appl

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Published December, 2020
By Toshiro Tango
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This book provides the application of generalized linear mixed-effects models and its related models in the statistical design and analysis of repeated measures adopted in randomized controlled trials. With increasing concerns about intra-patient variability of treatment effects, the traditional ANCOVA-type methods can no longer cope with these

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Published December, 2020
By Mohamed M. Shoukri
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

Presenting in depth discussions of various statistical models and methods needed for the analysis of medical, biological and biostatistics data, this book emphasizes the analysis of data when normal distribution assumptions are not tenable. It provides detailed explanations in situations when data are naturally clustered in groups, whereby the I

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