Main description:

In this volume devoted to systemic lupus erythematosus (SLE) and Sjoegren syndrome, leading specialists from different disciplines present the latest research findings on many aspects of the diseases and describe the most recent trends in treatment, such as the "treat to target" approach. Both basic science and clinical medicine are addressed, with emphasis on the most promising clinical and laboratory-based studies. The coverage is comprehensive in scope, encompassing, for example, epidemiology, pathogenesis, autoantibodies and biomarkers, disease manifestations, involvement of different organs or systems, relationships with other disorders, biological therapy of SLE, and systemic treatment of Sjoegren syndrome. Readers will find this first volume of Connective Tissue Disease to be an excellent source of information on the current understanding of, and clinical approach to, SLE and Sjoegren syndrome that clearly conveys the progress made in recent years.

Contents:

Part 1 Systemic Lupus Erythematosus.- Introduction - SLE in 21st Century.- Epidemiologic aspects of SLE.- Immunopathogenesis of SLE.- Clinical aspects in SLE.- Autoantibodies and biomarkers: diagnostic aspects.- Joint involvement in Systemic Lupus Erythematosus.- Cutaneous manifestations of SLE.- Kidney Involvement in SLE.- NPSLE.- Cardiovascular issues in SLE.- SLE and Pregnancy.- Vitamin D endocrine system and SLE.- The impact of aPL detection on pregnancy.- SLE and APS.- Disease activity indices and prognosis of SLE.- Conventional therapy for SLE.- Biological Therapy in SLE.- Part 2 Sjoegren Syndrome.- Classification criteria for Sjoegren syndrome.- Pathogenesis of Sjoegren syndrome.- Autoantibodies in Sjoegren syndrome and laboratory markers.- Parotid and Submandibular involvement in Sjoegren syndrome.- Extraglandular involvement in Sjoegren syndrome.- Dry eye in Sjoegren syndrome: diagnostic tools and therapy.- Neurologic involvement in Sjoegren syndrome.- Lymphoproliferative disorder in Sjoegren syndrome.- Pathogenetic aspects of Sjogren Syndrome: Relationships with Cryoglobulinemia and Lymphoproliferation.- Systemic treatment of Sjoegren syndrome.