Main description:

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more.

Contents:

1. Intrinsic disorder and phase transitions: Pieces in the puzzling role of the prion protein in health and disease

Mariana J. do Amaral and Yraima Cordeiro

2. Functions of intrinsically disordered proteins through evolutionary lenses

Matyas Pajkos and Zsuzsanna Dosztanyi

3. Non-specific porins of Gram-negative bacteria as proteins containing intrinsically disordered regions with amyloidogenic potential

Olga D. Novikova, Vladimir N. Uversky and Elena A. Zelepuga

4. Intrinsic disorder in integral membrane proteins

Brian J. Aneskievich, Rambon Shamilov and Olga Vinogradova

5. Molecular simulations of IDPs: From ensemble generation to IDP interactions leading to disorder-to-order transitions

Hebah Fatafta, Suman Samantray, Abdallah Sayyed-Ahmad, Orkid Coskuner-Weber and Birgit Strodel

6. Target-binding behavior of IDPs via pre-structured motifs

Do-Hyoung Kim and Kyou-Hoon Han

7. The role of dancing duplexes in biology and disease

Heather M. Forsythe and Elisar Barbar

8. Intrinsic disorder in protein kinase A anchoring proteins signaling complexes

Mateusz Dyla and Magnus Kjaergaard

9. Protein intrinsic disorder on a dynamic nucleosomal landscape

Sveinn Bjarnason, Sarah F. Ruidiaz, Jordan McIvor, Davide Mercadante and Petur O. Heidarsson

10. Flexible spandrels of the global plant virome: Proteomic-wide evolutionary patterns of structural intrinsic protein disorder elucidate modulation at the functional virus-host interplay

Rachid Tahzima, Annelies Haegeman, Sebastien Massart and Eugenie Hebrard