Main description:

This book highlights the importance of endothelial cells as key players in the functioning of the nervous system under both normal and pathological conditions. The book demonstrates that endothelial cells are an essential and dynamic cell population in the central nervous system, with multiple and complex roles, not only in the maintenance of homeostasis, but also in the regulation of important processes. These include neurogenesis, neural control of reproduction, aging, neurodegeneration, and tumor invasion. The book exhaustively reviews the newest findings in this exciting new area of investigation.

Contents:

Embryonic Development of the Brain Vascular System. Endothelial Cells and Maintenance of Neurogenic Niches during Embryonic Development and Adult Life. Alterations of Brain Endothelial Cells in Drug-Resistant Epilepsy: Drug Transporters. Dynamic Control of Endothelial Cells in Neural Reproduction Centers. Blood Vessel Remodeling After Stroke. Systemic Vascular Alterations and Neurodegenerative Diseases. Endothelial Cells, Alzheimer Disease and Metabolic Syndrome. Micro-Vascular Dysfunction After Spinal Cord Injury. Angiogenesis During Tumor Proliferation and Cell Invasion. Neuronal-Glial-Endothelial Interactions Regulate Central Nervous System Homeostasis.