Main description:

Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more.

Contents:

1. Overview of genetic models of autism spectrum disorders Jheel Patel, Jodi Lukkes and Anantha Shekhar 2. Neurofibromatosis type 1 as a model system to study molecular mechanisms of autism spectrum disorder symptoms Andrei I. Molosh and Anantha Shekhar 3. ERK/MAPK signaling and autism spectrum disorders Joseph Vithayathil, Joanna Pucilowska and Gary E. Landreth 4. From bedside to bench and back: Translating ASD models Drozd H. P., S.F. Karathanasis S. F., Molosh A, Lukkes J, D. Wade Clapp and A. Shekhar 5. Studying child development in genetic models of ASD Shruti Garg and Jonathan Green 6. Measurement considerations in pediatric research on autism spectrum disorders Karin S. Walsh and Srishti Rau