Main description:

Human Gonadotropins is a must-have reference for basic science researchers looking to maximize their knowledge in this specific field of study. Luteinizing hormone, follicle-stimulating hormone, and human chorionic gonadotropin are essential for reproduction and outlined in detail in this work, covering topics ranging from antibodies and immunoassays, to commercial products and standards, genetics, and receptors and intermediaries for gonadotropins. Dr. Laurence Cole has been recognized for his outstanding research throughout his illustrious career. He has received awards from the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research. This detailed resource compiles all the recent research together into one volume, with one consistent voice.

Contents:

A. Evolution
1. Evolution of Aa, GAH, FSH and LH
2. Evolution of CG and Development of Humans

B. Structure of the Gonadotropins
3. Structure FSH Peptide/arbohydrate/3D Construction
4. Structure LH Peptide/Carbohydrate/3D Construction
5. Structure hCG Peptide/Carbohydrate/3D Construction
6. Multiple forms of hCG Peptide/Carbohydrate/3D Construction

C. Synthesis of the Gonadotropins
7. Synthesis of the Gonadotropins

D. Functions of the Gonadotropins
8. Functions of Gonadotropin Releasing Hormone and Inhibin
9. Function of FSH
10. Function of LH
11. Function of Hormone hCG
12. Function of Hyperglycosylated hCG and Extravillous Cytotrophoblast hCG

E. Degradation of the Gonadotropins
13. Degradation hCG

F. Antibodies and Immunoassays for the Gonadotropins
14. Antibodies and Immunoassays for hCG

G. Commercial products and standards for Gonadotropins
15. Commercial Products and Standards for FSH
16. Commercial Products and Standards for LH
17. Commercial Products and Standards for hCG

H. The Genetics of Gonadotropins
18. The genetics of FSH
19. The genetics of hCG and LH

I. Sex Steroid Hormones
20. Estrogens and Progestogens
21. Male Steroidogenesis

J. Female Reproduction
22. Female reproduction: Follicle Formation and Follicle Selection
23. Female reproduction: Ovulation and Luteinization
24. Fertilization and Blastocyst Formation
25. Illicit use of hCG in Dietary Programs and to Promote Anabolism

K. Male Reproduction
26. Male Reproduction: sperm formation
27. Sperm Activation

L. Adrenarche and Menarche
28. Adrenarche and Menarche in Girls
29. Adrenarche and Puberty in Boys

M. Menstrual Cycle hCG
30. Pituitary Sulfated hCG
31. Hyperglycosylated hCG and Extravillous Cytotrophoblast hCG

N. Pregnancy
32. hCG and Pregnancy Tests
33. False-positive hCG Pregnancy Tests
34. hCG and Pregnancy
35. Implantation and Pregnancy Failure
36. Deep Implantation, hCG and Gestational Hypertension, Preeclampsia

O. Roles of Gonadotropins in Reproduction and Cancer
37. hCG and Gestational Trophoblastic Diseases
38. The Human Brain: Sexuality
39. Ovarian Cystic Disorders
40. hCG and Choriocarcinoma
41. hCG and Cancer

P. Receptors and intermediaries for Gonadotropins
42. Hyperglycosylated hCG, Extravillous Cytotrophoblast hCG and TGFss Receptor 2
43. Receptor and Intermediators for FSH
44. Receptor and Intermediaries for LH and the Hormone hCG