Main description:

The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the body through the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoveries since the last edition, Inhalation Toxicology, Third Edition presents contributions from internationally recognized scientists in the academic, commercial/industrial, and governmental sectors. A pragmatic resource for practicing professionals and students, the book comprehensively examines the relationship between the respiratory system and the toxicology of inhaled substances.

Topics include:

Regulatory aspects of exposure and testing

Testing equipment and procedures

Respiratory allergy and irritation of the respiratory tract

Risk assessment

Toxicology theory

Toxicology modeling

Toxic effects of some individual toxicants

New topics in this third edition include collection and characterization of airborne particulate matter, the inhalation toxicology of asbestos fibers and nanoparticles, and the development of lung-on-a-chip technology for predicting in vivo responses. Each chapter concludes with thought-provoking questions and answers, enhancing the book's educational utility.

Contents:

Collection and Characterization of Particulate Matter Deposition. Nose-Only Aerosol Exposure Systems: Design, Operation, and Performance. Lungs-on-a-Chip. Human Health Risk Assessment of Inhaled Materials. Application of Inhalation Toxicology Concepts to Risk and Consequence Assessments. Time Scaling of Dose and Time to Response: The Toxic Load Exponent. Improper Use of Haber's Law Results in Erroneous Fatality Estimation from Predictive Models. Physiologically Based Kinetic Modeling of Inhalation. Nanomaterial Inhalation Exposure from Nanotechnology-Based Consumer Products. Influence of Physicochemical Properties on the Bioactivity of Carbon Nanotubes/Nanofibers and Metal Oxide Nanoparticles. Inhalation Toxicology of Riot Control Agents. Incapacitating Agents. Exposure to Ammonia. Serpentine and Amphibole Asbestos. Pulmonary Primary Cells Cocultured in a Novel Cell Culture System, the Integrated Discrete Multiple Cell-Type Coculture System (IdMOC): Pulmonary Cytotoxicity of Eight Cigarette Smoke Condensates and Nicotine. Animal Models of Chronic Obstructive Pulmonary Disease (COPD). Toxic Inhalation Injury: Management and Medical Treatment. Transcriptomic Responses to Crystalline Silica Exposure. Mechanisms Involved in the Inhalation Toxicity of Phosgene. Chemical Warfare Agents and Nuclear Weapons. Emergency Response Planning Guidelines. Safety Assessment of Therapeutic Agents Administered by the Respiratory Routes. Index.