Main description:

Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine.

Essentially all major biological activities are performed by assemblies of macromolecules (proteins, RNA, and DNA) acting in concert. These assemblies are dynamic and many are endowed with machine-like properties. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.

Contents:

1. The Machines and Assemblies of Life
2. Chromatin
3. DNA Replication
4. DNA Repair and Recombination
5. Transcription
6. Protein Synthesis and Folding
7. Intracellular Proteolysis: Protein Quality Control and Regulatory Turnover
8. Assembly of Viruses
9. Multienzyme Complexes: Catalytic Nanomachines
10. Transport
11. Connectivity and Communication
12. Signaling
13. The cell cycle and cell death
14. Motility
15. Bioenergetics
16. Membrane Channels and Transporters
17. Complexes of the Immune System