Main description:

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients.

Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective.

Contents:

1. Introduction and basic biology of NK cells
2. Immunotherapy using CAR/NK with and without CAR/T
3. Immunotherapy using NK cells with and without T cells and Tumor infiltrating lymphocytes as well as NK/T cells
4. Autologous vs allogeneic sources of NK and T cell effectors
5. Reversing NK inhibitory tumor microenvironment by targeting suppressive immune effectors
6. Check point inhibitors
7. Combination of NK immunotherapy with chemotherapy and radiation
8. NK cell immunotherapy using ADCC inducing antibodies
9. Oncolytic viruses and NK cell immunotherapy
10. NK cell diagnostics
11. Novel cell delivery systems