Main description:

This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases.

The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems.

The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus.

Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture.

This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Contents:

1. Almouzni Pettinotti Genevieve genevieve.almouzni@curie.fr Research center at the Institut Curie, Head of the Chromatin Dynamics team , Member of the Science Academy in France, Co-Chair of the LifeTime Initiative, website https://lifetime-fetflagship.eu Histone H3 variants - chaperones and their contribution to nuclear architecture
2. Borsuk Ewa, Kubiak J.Z, Kloc MDep. Embryology, University of Warsaw, Warsaw Polandborsuk@biol.uw.edu.pl Histones modifications in mouse pronuclei and their consequences for embryo development
3. Bridger Joanna Joanna.Bridger@brunel.ac.uk Brunel University London, Biosciences, Dept of Life SciencesCollege of Health , Medical and Life Sciences (CHMLS), Institute Environment, Health and Societies, Brunel University London, Uxbridge, UB8 3PH, United KingdomT +44(0)1895 274000Joanna M. Bridger; Annabelle Lewis, Cristina Pina, Sabrina Tosi, Paola Vagnarelli.Alterations to genome organisation in cellular differentiation and disease.
4. Burgess Sean M. smburgess@ucdavis.edu University of California Davis, One Shields Avenue, Davis, CA 95616 Phone: 530 754 5177Email: smburgess@ucdavis.edu Meiotic chromosome dynamics in zebrafish
5. Capelson, Maya capelson@pennmedicine.upenn.edu Department of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAThe role of nuclear envelope/nuclear pore components in gene regulation.
6. Coverley Dawn dawn.coverley@york.ac.uk; and Grace DobbsDepartment of Biology, University of York, York YO10 5DD, United KingdomNuclear condensation and chromosome rearrangement in quiescence in relation to compromised functionality in cancer cells
7. Faustino Randolph S. randolph.faustino@sanfordhealth.org Genetics and Genomics Group, Sanford Research, 2301 East 60th St. N, Sioux Falls, SD 57104, USA, Phone #: (605) 312-6443Roles for nuclear pores in differentiation
8. Frietze Seth E seth.frietze@med.uvm.edu , and Karen Glass, Joeseph Boyd, Kate Quinn, Cong Gao University of Vermont, Burlington, VT, USAEvaluation of chromatin regulatory factors across the molecular subtypes of breast cancer
9. Gerton, Jennifer JEG@stowers.org , and Alexandria Cockrell Stowers Institute for Medical Research, Kansas City, MO, USANucleolar organizer regions
10. Guichet Antoine Antoine.GUICHET@ijm.fr Morphogenesis and Polarity Unit, Institut Jacques Monod, 75005 Paris, France; and Quantitative Image Analysis Unit, Institut Pasteur, 75724 Paris, FranceMicrotubules and Nuclear positioning in Drosophila
11. Hausmann Michael hausmann@kip.uni-heidelberg.de Kirchhoff-Institute for Physics, Heidelberg University, Im Neuenheimer Feld 227, 69120 Heidelberg, GermanyMichael Hausmann, Martin Falk, Goetz Pilarczyk, Georg Hildenbrand et al.Network and Islands of Genome Nanoarchitecture and their Potential Relevance for Radiation Biology
12. Hieda Miki (Matsumura) mikihieda@gmail.com Osaka University, Graduate School of Medicine and Health Science, Suita City, Osaka, Japan, and Ehime Prefectural University of Health Science, s, Tobe-cho, Ehime, JapanThe interplay between nucleoskeleton and cytoskeleton.
13. Huang Yuanjian. yhuang14@mdanderson.org; Zhang Shengzhe.SZhang23@mdanderson.org; Park Jae-Il. jaeil@mdanderson.org
Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd.Unit 1052, Houston, TX 77030Nuclear Actin Dynamics in Orchestrating Gene Expression
14. Kimura Akatsuki akkimura@nig.ac.jp ; and Dr. Takahiro Sakaue (Aoyama Gakuin University, Japan, sakaue@phys.aoyama.ac.jp Cell Architecture Laboratory, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, JAPAN, Phone: +81-55-981-5854How nuclear size affects physical properties and functions of chromatin
15. Knoch Tobias Aurelius ta.knoch@taknoch.org Biophysical Genomics Group, Department of Cell Biology and Genetics, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The NetherlandsHow Genomes Emerge, Function, and Evolve: Living Systems Creation - Genotype-Phenotype-Multilism - Genome/Systems Ecology, or3D organization in respect to polymer simulations of entire cell nuclei, orWhat we can learn from various experiments finalizing the 3D structure, whether we can understand this and what follows, orNew evaluation of interaction mapping data
16. Latonen Leena leena.latonen@uef.fi K. Albin Johansson Cancer Research Fellow, Institute of Biomedicine, University of Eastern Finland, PO BOX 1627, 70211 Kuopio, Finland, tel: +358-50-3465553leena.latonen@uef.fi Nuclear organization, especially focusing on responses to stress and drug treatments
17. Lele Tanmay P tanmay.lele@tamu.edu Texas A&M University Department of Biomedical Engineering, College Station, TexasNuclear structure in cancer
18. Maiuri Paolo paolo.maiuri@ifom.eu ; and Paulina Nastaly\IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, ItalyTransmitting the cell polarity to the nucleus
19. Mullins Dyche R. dyche.mullins@ucsf.edu University of California, San Francisco, Howard Hughes Medical InstitutesTel. 415-502-4838 Title???
20. O'Sullivan Justin justin.osullivan@auckland.ac.nz The Liggins Institute, The University of Auckland, Auckland, New ZealandIntegrating multimorbidity into a whole of body understanding of disease using spatial genomics.
21. Percipalle Piergiorgio pp69@nyu.edu Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm SE-171 77, SwedenThe role of cytoskeletal proteins in genomic architecture during differentiation
22. Ruan Yijun Yijun.Ruan@jax.org The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA,and Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT 06030, USAExploring the topological architecture in complex genetics of polygenic traits and diseases
23. Stein Gary S Gary.Stein@med.uvm.edu Department of Biochemistry and University of Vermont Cancer Center, Robert Larner College of Medicine, University of Vermont, Burlington, VT 05405, USAEpigenetic-mediated regulation of gene expression for biological control and cancer
24. Takizawa Takumi takizawt@gunma-u.ac.jp Department of Pediatrics, Graduate School of Medicine, Gunma University 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, JapanPhone: +81-27-220-8203 / 8479Nuclear architecture in the nervous system
25. Takashi Mikawa Takashi.Mikawa@ucsf.edu University of California San Francisco, Cardiovascular Research Institute, 555 Mission Bay Blvd South, MC3120, Room 352Z, PO Box 589001, San Francisco, CA 94158-9001Office:415-476-3230. Lab:415-476-3231Positioning of paternal and maternal chromosome sets
26. Tsuchiya Masa tsuchiya.masa@gmail.com Systems Biology Program, School of Media and Governance, Keio University, Fujisawa, JapanGenomic Control Mechanism of Cell-Fate Changes
27. Ward Steven W. wward@hawaii.edu Institute for Biogenesis Research, Dept. Anatomy, Biochemistry & Physiology, Chief, Research Division Lakshmi Devi and Devraj Sharma Endowed Chair, Dept. OB/GYN and Women's Health John A. Burns School of Medicine, University of Hawaii at Manoa, 1960 East-West Rd. Honolulu, HI 96822 Tel: 808-956-5189Functional Aspects of Sperm Chromatin Organization.
28. Uversky, Vladimir vuversky@usf.edu NOT CONFIRMED