Main description:

This book contains most of the scientific contributions during the 48th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), which was held electronically in July 2021. It includes multidisciplinary contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians and covers covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence.

Contents:

1. Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury2. Imaging cerebral energy metabolism in healthy infants

3. Changes in cerebral oxygenation and systemic physiology during a verbal fluency task: Differences between men and women

4. Brain Tissue Conductivity in Focal Cerebral Ischemia

5. Physical stress Attenuates Cognitive inhibition: An fNIRS Examination

6. Changes in Prefrontal Cortical Oxygenation During Tilt Table Orthostatic Hypotension in Subarachnoid Haemorrhage Patients

7. Effects of different optical properties of head tissues on near-infrared spectroscopy Using Monte Carlo Simulations

8. Frontal cerebral oxygenation in humans at rest: A mirror symmetry in the correlation with cardiorespiratory activity

9. Photomodulation of lymphatic delivery of bevacizumab to the brain: the role of singlet oxygen

10. NIRS-based study of local cerebral oxygenation during transcranial direct current stimulation in patients with mild traumatic brain injury

11. Postnatal Exposure to Brief Hypoxia Alters Brain VEGF Expression and Capillary Density in Adult Mice

12. Impaired Cognitive Performance in Mice Exposed to Prolonged Hyperoxia

13. Chronic Ketosis Modulates HIF1 -Mediated Inflammatory Response in Rat Brain

14. Motor Imagery and Frontal Head Oxygenation: An fNIRS Study

15. Non-invasive detection of persistent cortical hypoxia in Multiple Sclerosis using frequency domain near-infrared spectroscopy (fdNIRS)

16. Evaluation of intraoperative end-tidal Carbon dioxide change relates to length hospitalization in peridiaphragmatic surgery: a pilot study

17. Pulmonary Embolism in COVID-19 patients is not related to a worsening in tissue oxygenation

18. Cardiovascular risk score and gas exchange in COVID-19 patients: no correlation

19. Heme Oxygenase 1/ High Mobility Group Box 1 pathway may have a possible role in Covid-19 ARDS (Acute respiratory distress syndrome): a pilot histological study

20. Silent Hypoxemia in COVID-19 pneumonia

21. Low Flow and Microvascular Shunts: A Final Common Pathway to Cerebrovascular Disease: A Working Hypothesis

22. A case of intracranial vertebral artery stenosis treated with percutaneous transluminal angioplasty and stenting guided by brain oximetry

23. Assessment of Optimal Arterial Pressure with Near-Infrared Spectroscopy in Traumatic Brain Injury Patients

24. Effects of exercise-diet therapy on cognitive function in healthy elderly people evaluated by deep learning based on basic blood test data

25. NIRS studies show reduced interhemispheric functional connectivity in individuals with Multiple Sclerosis that exhibit cortical hypoxia

26. Eye Tracking Parameters Correlate With the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study

27. Critical closing pressure of cerebral circulation at concomitant moderate-to-severe traumatic brain injury

28. Hybrid convolutional neural network (hCNN) for image reconstruction in near-infrared optical tomography

29. Cross-frequency coupling between brain and body biosignals: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study

30. Machine learning distinguishes familiar from unfamiliar pairs of subjects performing an eye contact task: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study

31. Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates With Asphyxia

32. Basic examination of hemoglobin phase of oxygenation and deoxygenation in resting state and task periods in adults using fNIRS

33. Development and validation of robust and cost-effective liquid heterogeneous phantom for time domain near-infrared optical tomography

34. Effect of Exercise Therapy on Stress Response Evaluated by IoMT Monitoring System

35. Improved optical tissue model for tissue oximetry imaging applications

36. In vitro validation of a new tissue oximeter using visible light

37. Photon and Proton Dose Painting based on Oxygen Distribution - Feasibility Study and Tumour Control Probability Assessment

38. Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells

39. Feasibility of non-invasive measurement of tumor NAD(H) by in vivo phosphorus-31 magnetic resonance spectroscopy

40. Acidosis-induced regulation of Egr1 and Ccn1 in vitro and in experimental tumors in vivo

41. Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours

42. Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers upon Mild Hyperthermia Delivered by wIRA-Irradiation

43. Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy

44. Optical Redox Imaging Is Responsive to TGF Receptor Signaling in Triple-Negative Breast Cancer Cells

45. Evaluation of betulinic acid derivatives as PET tracers for hypoxia-induced carbonic anhydrase IX (CA IX) expression

46. Role of the mTOR signaling pathway during extracellular acidosis in tumor cells

47. Feasibility Study of Remote Contactless Perfusion Imaging with Consumer-Grade Mobile Camera

48. Stability of a Novel PEGylation site on a Putative Hemoglobin Based Oxygen Carrier

49. Oxygen storage in stacked phospholipid membranes under an oxygen gradient as a model for myelin sheaths

50. Confocal laser and electron microscopic investigation of gap junctions in anaplastic astrocytomas

51. A radiation biological analysis of the oxygen effect as a possible mechanism in FLASH

52. Assessment of nicotinamide adenine dinucleotide in human tissues by in vivo phosphorus-31 magnetic resonance spectroscopic imaging at 1.5 Tesla

53. Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus

54. Hemorheologic Enhancement of Cerebral Perfusion increases oxygen supply and reduces Ab plaques deposition in a mouse model of Alzheimer's Disease

55. Calorimetric Characterization of the Binding Reaction Between Human Ferric Hemoglobins and Haptoglobin to Develop a Drug for Removal of Cell-Free Haemoglobin

56. Feasibility To Measure Tissue Oxygen Saturation Using Textile-integrated Polymer Optical Fibers

57. Effect of Atorvastatin on Microcirculation Evaluated by Vascular Occlusion Test with Peripheral Near lnfrared Spectroscop

58. Flow characteristics of the conjugate of anti-CD3 monoclonal antibodies and magnetic nanoparticle in the PBS and the blood vessel

59. Cerebrovascular Reserve (CVR) and Stages of Hemodynamic Compromise

60. On the mechanism of sustained mitochondrial membrane potential without functioning complex IV

61. Further evidence that gradients of extracellular pH direct migration of MDA-MB-231 cells in vitro

62. Blood Flow and Respiratory Gas Exchange in the Human Placenta at Term: A Data Update

63. Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats

64. Changes in Oxygenation Levels During Moderate Altitude Simulation (Hypoxia-Induced): A Pilot Study Investigating the Impact of Skin Pigmentation in Pulse Oximetry

65. The Intramuscular Circulation is Affected by Neck and Shoulder Pain

66. Intramuscular circulation of the lumbar multifidus in different trunk positions on standing

67. Numerical Optimization of a NIRS Device for Monitoring Tissue Oxygen Saturation

68. Upper trapezius muscle tonicity, assessed by palpation, relates to change in tissue oxygenation and structure as measured by Time-Domain Near Infrared Spectroscopy

69. Perceived exertion correlates with multiple physiological parameters during cardiopulmonary exercise testing

70. Systemic and Quadriceps Muscle O2 Dynamics in Subjects without Attenuation Point of Deoxygenated Hemoglobin Concentration during Ramp Cycling Exercise

71. Jaw-Clenching Intensity Effects on Masseter Oxygen Dynamics and Fatigue: A NIRS Oximetry Study