Geared to residents and fellows in nephrology, internal medicine, and other specialties, this classic text bridges the gap between basic and clinical sciences for the many disorders associated with electrolyte imbalances and kidney dysfunction. This edition has been thoroughly revised by world-renowned contributors to reflect recent developments in renal pathophysiology. Highlights include completely updated information on the role of the kidney in hypertension, afferent and efferent mechanisms of renal sodium retention, and delineation of mutation defects causing congenital nephrogenic diabetes insipidus.

Each chapter begins with normal function and pathophysiology and quickly moves to clinical conditions and treatment. Numerous illustrations, tables, charts, and graphs make complex subjects understandable. Up-to-date references are also included.

1: Disorders of Water Metabolism

Tomas Berl and Robert W. Schrier

2: Renal Sodium Excretion, Edematous Disorders, and Diuretic Use

Robert W. Schrier

3: Pathogenesis and Management of Metabolic Acidosis and Alkalosis

Shobha Ratnam, William Kaehny, and Joseph I. Shapiro

4: Pathogenesis and Management of Respiratory and Mixed Acid-Base Disorders

William D. Kaehny

5: Disorders of Potassium Metabolism

Biff F. Palmer and Thomas D. DuBose, Jr.

6: Disorders of Calcium, Phosphorus, Vitamin D, and Parathyroid Hormone Activity

Mordecai M. Popovtzer

7: Normal and Abnormal Magnesium Homeostasis

David M. Spiegel

8: Disorders of the Renin-Angiotensin-Aldosterone System

Matthew K. Abramowitz, Manish P. Ponda, and Thomas H. Hostetter

9: The Kidney in Hypertension

Charles R. Nolan and Robert W. Schrier

10: Acute Kidney Injury: Pathogenesis, Diagnosis, and Management

Robert W. Schrier and Charles L. Edelstein

11: Chronic Kidney Disease: Manifestations and Pathogenesis

Michel B. Chonchol and Laurence Chan

12: Obstructive Nephropathy: Pathophysiology and Management

Kevin P.G. Harris

13: Renal Function and Pregnancy

Arun Jeyabalan and Kirk P. Conrad

14: Proteinuria and the Nephrotic Syndrome

Burl R. Don and George A. Kaysen

15: The Glomerulopathies

Joshua Thurman and Ryan Goldberg