Main description:

Ribonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression.

However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems). Therefore, cells have developed mechanisms to protect and/or repair RNA molecules.

This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases.

Contents:

Book Title: RNA Damage and Repair
ToC

Preface

RNA Damage and Repair in Prokaryotes

Chapter 1 - Endoribonucleases of the toxin-antitoxin systems induce abortive infection
Yuichi Otsuka

Chapter 2 - The lifecycle of ribosomal RNA in bacteria
Maria Grazia Giuliano, Christoph Engl

Chapter 3 - The Rtc RNA end healing and sealing system
Danai Athina Irakleidi, Harry Beaven, Martin Buck, Ioly Kotta-Loizou

RNA Damage and Repair in Eukaryotes

Chapter 4 - Oxidative and nitrative RNA modifications in plants
Jagna Chmielowska-Bak, Karolina Izbianska-Jankowska, Magdalena Arasimowicz-Jelonek, Joanna Deckert, Jolanta Floryszak-Wieczorek

Chapter 5 - The role of ribonucleases in RNA damage, inactivation, and degradation
Fabian Hia and Osamu Takeuchi

Chapter 6 - Cytoplasmic mRNA recapping: An unexpected form of RNA repair
Daniel R. Schoenberg

RNA Damage in Human Diseases

Chapter 7 - Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases
Priyankaa Pitcheshwar, Haoqing Shen, Jian Han, Sze Jing Tang

Chapter 8 - RNA-mediated metabolic defects in microsatellite expansion diseases
Nan Zhang