Main description:

This book demonstrates how the latest insights into the physiopathology of the stress response can be integrated into clinical practice. The topic is particularly relevant since the metabolic changes triggered by acute stress, including adaptive responses such as resistance to anabolic signals, have recently been more precisely delineated. The underlying mechanisms of these changes are also now better understood. The authors analyse how these advances could result in better management and more effective prevention of the long-term clinical consequences of the alterations occurring during the acute phase. An international panel of respected experts discusses these topics and describes the management of some common clinical conditions.

Contents:

Foreword.- Introduction.- Part 1: Metabolic changes.- Successive phases.- Bioenergetics of the stress response.- Hibernation and mitochondrial adaptation.- Resistance to anabolic signals.- Use of lipids as energy substrates.- Use of carbohydrates.- Stress hyperglycemia.- Protein metabolism.- Micronutrients.- Part 2: Hormonal regulation.- Hypothalamic-pituitary axis.- Thyroid.- Adrenal.- Sex hormones.- Enterohormones.- Adipokines.- Part 3: Particular clinical situations.- Severe undernutrition.- Traumatic brain injury.- Sepsis and MOF.- Morbid obesity.- Burn injury.