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Main description:
The haemostatic system is one the most important physiological systems for maintaining health and well being, and thus the investigation of the haemostatic system remains a research priority. Disturbances of the haemostatic system in the broader sense, such as heart disease and strokes, arguably constitute the single greatest contribution to non-infectious mortality in the world today. Therefore, understanding the laboratory methods to assess the haemostatic system is vital for the practice of complex clinical medicine. In Haemostasis: Methods and Protocols, experts in the field address the major components of the haemostatic system, general principles of haemostatic testing, and techniques used to assess various aspects of the haemostatic system, grouped according to their functional indications. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and easily accessible, Haemostasis: Methods and Protocols provides an ideal guide to scientists of all backgrounds and serves an urgent need for further research to develop superior methods of assessing the haemostatic system in humans.
Contents:
Part I. The Haemostatic System
1. The Coagulation System in Humans
Anthony K. C. Chan and Nethnapha Paredes
2. Platelet Physiology
Matthew D. Linden
3. The Role of the Blood Vessel Wall
Nethnapha Paredes and Anthony K. C. Chan
Part II. General Principles of Haemostatic Testing
4. Specimen Requirements for the Haemostasis Laboratory
Linda Stang and Lesley G. Mitchell
5. Principles of Haemostasis Tests
Gemma Crighton
6. Reference Ranges of Coagulation Tests
Oliver Speer, Markus Schmugge, Claudia Metzger, and Manuela Albisetti
7. Lupus Anticoagulant Testing
Karen Moffat, Anne Raby, and Mark Crowther
Part III. Examples of Global Tests of Haemostasis
8. Activated Partial Thromboplastin Time (APTT)
Vera Ignjatovic
9. Prothrombin Time (PT) and International Normalised Ratio (INR)
Vera Ignjatovic
10. Thrombin Clotting Time (TCT)
Vera Ignjatovic
11. Thrombin Generation
Leslie R. Berry and Anthony K. C. Chan
12. Activated Clotting Time (ACT)
Stephen Horton and Simon Augustin
Part IV. Examples of Tests for Bleeding Disorders
13. Factor XII Assays
Stephen Opat, Jenny Butler, Erica Malan, Elizabeth Duncan, and Huyen A.M. Tran
14. Fibrinogen
Linda Stang and Lesley G. Mitchell
15. Platelet Counting
Sylvain Salignac, Veronique Latger-Cannard, Nicole Schlegel, and Thomas Lecompte
16. Platelet Morphology Analysis
Veronique Latger-Cannard, Odile Fenneteau, Sylvain Salignac, Thomas Lecompte, and Nicole Schlegel
17. Light Transmission Aggregometry
Juan Pablo Frontroth
18. Platelet Flow Cytometry
Matthew D. Linden
Part V. Examples of Specific Assays Related to Anticoagulant Activity
19. Anti-factor Xa assay (anti-Xa)
Fiona Newall
20. Reptilase Time (RT)
Hratsch Karapetian
21. Protamine Titration
Fiona Newall
22. Laboratory Methods for the Assay if Tissue Factor Pathway Inhibitor (TFPI) in Human Plasma
Robyn Summerhayes
23. Heparin Induced Thrombocytopenia (HIT)
Andreas Greinacher, Birgitt Furll, and Sixten Selleng
Part VI. Examples of Tests for Inhibitors of Coagulation
24. Nijmegen-Bethesda Assay to Measure Factor VIII Inhibitors
Elizabeth Duncan, Margaret Collecutt, and Alison Street
25. Kaolin Clotting Time
Kottayam Radhakrishnan
26. The Dilute Russell Viper Venom Time (DRVVT)
Kottayam Radhakrishnan
27. Platelet Neutralisation Test
Kottayam Radhakrishnan
Part VII. Examples of Tests for Increased Risk of Thrombosis
28. Antithrombin
Mirta Hepner and Vasiliko Karlaftis
29. Protein C
Mirta Hepner and Vasiliki Karlaftis
30. Protein S
Mirta Hepner and Vasiliki Karlaftis
31. Testing for Hyperhomocysteinemia in Subjects with a History of Thromboembolic Events Using HPLC Technique
Jonas Denecke
32. Anticardiolipin Antibody and Anti-Beta 2 Glycoprotetin I Assays
Anne Raby, Karen Moffat, and Mark Crowther
33. Testing for Apolipoprotein (a) Phenotype Using Isoelectric Focusing and Immunoblotting Technique
Claus Langer, Bertram Tambyrayah, and Ulrike Nowak-Goettl
Part VIII. Examples of Measures of Fibrinolysis
34. D-Dimer and Fibrinogen/Fibrin Degradation Products
Linda Stang
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: April, 2013
Pages: 444
Weight: 9732g
Availability: Available
Subcategories: General Issues, Haematology
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